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| Product Name | Recombinant Clostridium botulinum Botulinum neurotoxin type A |
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| Description | 1-436aa; Partial. MW: 65.94kD. Purity >90% as determined by SDS-PAGE. Inhibits acetylcholine release. The botulinum toxin binds with high affinity to peripheral neuronal presynaptic membrane to the secretory vesicle protein SV2. It binds directly to the largest luminal loop of SV2A, SV2B and SV2C. It is then internalized by receptor-mediated endocytosis. The C-terminus of the heavy chain (H) is responsible for the adherence of the toxin to the cell surface while the N-terminus mediates transport |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Bontoxilysin-A; BOTOX] |
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| Gene, Accession, CAS # | botA, Accession: WP_003356619.1 |
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| Catalog # | MBS1068389 |
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| Order / More Info | Recombinant Clostridium botulinum Botulinum neurotoxin type A from MYBIOSOURCE INC. |
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| Product Specific References | The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene.Thompson D.E., Brehm J.K., Oultram J.D., Swinfield T.-J., Shone C.C., Atkinson T., Melling J., Minton N.P.Eur. J. Biochem. 189:73-81(1990) The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins.Binz T., Kurazono H., Wille M., Frevert J., Wernars K., Niemann H.J. Biol. Chem. 265:9153-9158(1990) Organization an |
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