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| Product Name | XPC, Recombinant, Human, aa496-734, His-Tag (DNA Repair Protein Complementing XP-C Cells) |
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| Description | Purity ~90% (SDS-PAGE). Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Xeroderma pigmentosum group C-complementing protein, p125 |
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| Gene, Accession, CAS # | SwissProt: Q01831 |
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| Catalog # | 375880 |
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| Order / More Info | XPC, Recombinant, Human, aa496-734, His-Tag (DNA Repair Protein Complementing XP-C Cells) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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