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| Product Name | EGLN3, Recombinant, Human, aa1-239, His-Tag (Egl nine homolog ) |
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| Description | Purity ~90% (SDS-PAGE). EGLN3, a member of the EGLN family of prolyl hydroxylases, has been shown to catalyze hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha, which targets hypoxia-inducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor. EGLN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. under normoxia, hydroxylates and regulates the stability of ADRB2. Source: Recombinant protein corresponding to aa1-239 of human EGLN3, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~29.8kD AA |
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| Size | 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_071356 |
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| Catalog # | 349880 |
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| Order / More Info | EGLN3, Recombinant, Human, aa1-239, His-Tag (Egl nine homolog ) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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