| 产品详情 |
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| Antigenic Specificity | EGLN1 / PHD2, aa1-24 |
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| Clone | 366G/76/3 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | peroxidase (HRP) conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC, IHC-P, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | EGLN1 / PHD2 Antibody (aa1-24, clone 366G/76/3, HRP) LS-C188436. Recognizes human prolyl hydroxylase 2 (PHD2), a 46kD enzyme expressed abundantly in all tissues with the highest expression in testis. Hypoxia inducible factor-1 (HIF-1) is a transcriptional complex, consisting of an alpha and beta subunit, which plays a key role in coordinating the cellular response to hypoxia. During normal oxygen conditions, the alpha subunit of HIF-1 is rapidly degraded, however when hypoxia occurs this degradation is suppressed and HIF-1 activates the transcription of various genes important for survival and adaptation to hypoxia. Prolyl hydroxylase 2 catalyses the hydroxylation of specific prolyl residues within the HIF-1 alpha subunit, thereby targeting this subunit for degradation. |
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| Immunogen | PHD2 amino acids 1-24. |
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| Other Names | EGLN1, C1orf12, EGL9, ECYT3, Egl nine-like protein 1, HIFPH2, HIF prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, ZMYND6, PHD2, SM20, EGL nine (C.elegans) homolog 1, Egl nine homolog 1, HPH-2, HPH2, SM-20 |
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| Gene, Accession # | EGLN1, Gene ID: 54583 |
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| Catalog # | LS-C188436 |
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| Price | |
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| Order / More Info | EGLN1 / PHD2, aa1-24 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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