| 产品详情 |
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| Product Name | Piericidin A |
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| Description | Purity >95%. Complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase (ubiquinone), catalyzes the transfer of electrons from NADH to ubiquinone (also known as coenzyme Q10 ) as part of the respiratory chain leading to ATP generation. Piericidin A is an irreversible inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. First identified as an insecticidal metabolite produced by Streptomyces, piericidin A was soon found to bind and inhibit complex I at nanomolar concentrations. The inhibition of complex I by piericidin A in the presence of NADH results in the generation of reactive oxygen species. In plants, pieridicin A inhibits photosystem II, a water-plastoquinone oxidoreductase involved in light-dependent electron transfer. Piericidin A also suppresses the up-regulation of the glucose-regulated protein GRP78 in glucose-deprived, etoposide-resistant HT-29 cells, resulting in cell death (IC50 = 7.7 nM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(2E,5E,7E,11E)-10R-hydroxy-3,7,9R,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol, AR 054, Shaoguanmycin B, SN 198E |
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| Gene, Accession, CAS # | CAS: 2738-64-9 |
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| Catalog # | LS-H9406 |
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| Price | |
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| Order / More Info | Piericidin A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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