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| Product Name | Recombinant Human Ryanodine receptor 1 |
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| Description | 1-534aa; Partial. MW: 63.4kD. Purity >90% as determined by SDS-PAGE. Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prol |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor] |
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| Gene, Accession, CAS # | RYR1, Gene ID: 6261, Accession: NP_000531.2 |
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| Catalog # | MBS962209 |
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| Order / More Info | Recombinant Human Ryanodine receptor 1 from MYBIOSOURCE INC. |
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| Product Specific References | Molecular cloning of cDNA encoding human and rabbit forms of the Ca2 release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.Zorzato F., Fujii J., Otsu K., Phillips M.S., Green N.M., Lai F.A., Meissner G., Maclennan D.H.J. Biol. Chem. 265:2244-2256(1990) Polymorphisms and deduced amino acid substitutions in the coding sequence of the ryanodine receptor (RYR1) gene in individuals with malignant hyperthermia.Gillard E.F., Otsu K., Fujii J., Duff C.L., de Leon S., Khanna V.K. |
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