| 产品详情 |
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| Product Name | SC-514 |
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| Description | Purity >98%. SC-514 is a selective and reversible inhibitor of I?B kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1Beta, SC-514 attenuates NF-?B-mediated expression of IL-6, IL-8, and cyclooxygenase-2 (IC50 s = 20, 20, and 8 µM, respectively). SC-514 also reduces NF-?B-mediated expression of other genes, including iNOS in LPS-stimulated smooth muscle cells3 and TLR2 in TNF-activated astrocytes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-amino-[2,3'-bithiophene]-5-carboxamide |
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| Gene, Accession, CAS # | CAS: 354812-17-2 |
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| Catalog # | LS-H9868 |
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| Price | |
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| Order / More Info | SC-514 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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