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| Product Name | SBC-115076 |
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| Description | Purity >98%. Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with important roles in lipoprotein metabolism. PCSK9 overexpression in wild-type mice doubles plasma total cholesterol, possibly through acceleration of degradation of the LDL receptor (LDLR). SBC-115076 is an inhibitor of PCSK9 action that blocks LDLR degradation in HEK293T cells expressing PCSK9. Through this mechanism, submicromolar concentrations of SBC-115076 increase the uptake of LDL by liver cells in vitro . SBC-115076 is effective in vivo, lowering cholesterol levels in mice that are fed a high fat diet. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,5-dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one |
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| Gene, Accession, CAS # | CAS: 489415-96-5 |
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| Catalog # | LS-H9858 |
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| Price | |
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| Order / More Info | SBC-115076 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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