| 产品详情 |
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| Product Name | SC-57461A |
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| Description | Purity >98%. Leukotriene A4 (LTA4 ) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. SC-57461A is a potent, orally active inhibitor of LTA4 hydrolase that blocks ionophore-stimulated LTB4 synthesis in whole blood (IC50 = 49 nM). It blocks both the hydrolase and aminopeptidase activity in vitro . SC-57461A is without effect against other enzymes of the arachidonic acid cascade, including 5-lipoxygenase, LTC4 synthase, COX-1, and COX-2. In a rat model of ionophore-induced peritoneal eicosanoid production, SC-57461A inhibits LTB4 biosynthesis without affecting LTC4 or 6-keto prostaglandin F1Alpha production . Oral or topical pretreatment with SC-57461A before challenge with arachidonic acid blocks ear edema in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-Beta-alanine, monohydrochloride |
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| Gene, Accession, CAS # | CAS: 423169-68-0 |
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| Catalog # | LS-H9867 |
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| Order / More Info | SC-57461A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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