| 产品详情 |
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| Product Name | Triptolide |
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| Description | Purity >98%. Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a gatekeeper enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 µM and an IC50 value of 7-10 nM. Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one, PG 490, NSC 163062 |
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| Gene, Accession, CAS # | CAS: 38748-32-2 |
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| Catalog # | LS-H10316 |
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| Order / More Info | Triptolide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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