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| Product Name | Mouse-/ Rat-LEPTIN ELISA |
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| Description | The Mouse/Rat Leptin ELISA utilizes two specific high affinity polyclonal antibodies for these proteins. It recognizes quantitatively mouse leptin. Standards are prepared of recombinant mouse leptin. A high degree of cross reactivity against rat leptin allows to use the kit also for measuring rat leptin. Dilutions of rat samples were found as linear as mouse samples. Preparations of recombinant mouse and rat leptin from the same producer were compared regarding their quantification with this kit E06. The relative potency of the rat material was found to be plus 95%, compared to the respective mouse material, and, based on the nominal declaration of the producer. When working with rat samples, individual own calibrating of the kit values is recommended. E06 is calibrated against the WHO NIBSC mouse leptin standard code 97/626. Species Reactivity: mouse, rat. Sample Types: serum, plasma. Range: 25 - 1600 pg/ml. Sensitivity: 10 pg/ml. Time: 3 hours • Leptin, the product of the ob gene (1,2), is a recently discovered single-chain proteohormone with a molecular weight of 16 kD which is thought to play a key role in the regulation of body weight. Its amino acid sequence exhibits no major homologies with other proteins (1). Leptin is almost exclusively produced by differentiated adipocytes (3-5). It acts on the central nervous system, in particular the hypothalamus, thereby suppressing food intake and stimulating energy expenditure (2,6-9). Leptin receptors - alternatively spliced forms exist that differ in length - belong to the cytokine class I receptor family (10-12). They are found ubiquitously in the body (10,11,13,14) indicating a general role of leptin which is currently not fully understood. A circulating form of the leptin receptor exists which acts as one of several leptin binding proteins (15). |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Leptin |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E06 |
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| Order / More Info | Mouse-/ Rat-LEPTIN ELISA from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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