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| Product Name | DHEA-S ELISA |
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| Description | In the DHEA-S ELISA Assay Kit, the (Antigens) in the sample competes with the Antigensic DHEA-S conjugated with horseradish peroxidase (HRP) for binding to the limited number of antibodies anti DHEA-S coated on the microplate (solid phase). After the incubation, the bound/free separation is performed by a simple solid-phase washing. Then, the enzyme HRP in the bound-fraction reacts with the Substrate (H2O2) and the TMB Substrate and develops a blu color that changes into yellow when the Stop Solution (H2SO4) is added. The colour intensity is inversely proportional to the DHEA-S concentration of in the sample. DHEA-S concentration in the sample is calculated through a calibration curve. Sample Types: serum, plasma. Range: 0.1 - 10 µg/mL. Sensitivity: 0.03 mg/mL. Time: 1.5 hours • Dehydroepiandrosterone sulfate (DHEA-S), is a natural steroid hormone found atop of the kidneys in the human body. DHEA-S derived from enzymatic conversion of DHEA in adrenal and extradrenal tissues. DHEA-S is also produced in the gonads, adipose tissue and the brain. It is the most abundant hormone in the human body and it is precursor of all sex Steroid. As most DHEA-S is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response. DHEA-S may have more biologic roles. Its production in the brain suggests that is also has a role as a neurosteroid. Measurement of serum DHEA-S is a useful marker of adrenal androgen synthesis. Abnormally low levels may occur in have been reported in hypoadrenalism, while elevated levels occur in several conditions, e.g. virilizing adrenal adenoma and carcinoma, 21-hydroxylase and 3β-hydroxysteroid dehydrogenase deficiencies and in some cases of female hirsutism. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEAS. As very little DHEA-S is produced by the gonads, measurement of DHEA-S levels may aid in the localization of androgen source in virilizing conditions. DHEA-S levels show no diurnal variation. |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | DHEA-S,Dehydroepiandrosterone sulfate,adrenal androgen synthesis |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | DCM005 |
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| Order / More Info | DHEA-S ELISA from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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