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| Product Name | TNF, Recombinant, Human, aa77-233, His-Tag (Tumor Necrosis Factor) |
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| Description | Purity ~90% (SDS-PAGE). Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Source: Recombinant protein corresponding to aa77-233 from human Tumor Necrosis Factor, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~21.4kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cachectin, TNF-alphaTumor necrosis factor ligand superfamily member 2, TNF-a |
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| Gene, Accession, CAS # | SwissProt: P01375 |
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| Catalog # | 375615 |
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| Order / More Info | TNF, Recombinant, Human, aa77-233, His-Tag (Tumor Necrosis Factor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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