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| Product Name | TNF, Recombinant, Rat |
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| Description | Purity ~95% (SDS-PAGE). TNF is secreted by macrophages, monocytes, neutrophils, T cells, natural killer cells following their stimulation by bacterial lipopolysaccharides. Cells expressing CD4 secrete TNF-alpha while CD8(+) cells secrete little or no TNF-alpha. Stimulated peripheral neutrophilic granulocytes but also unstimulated cells and also a number of transformed cell lines, astrocytes, microglial cells, smooth muscle cells, and fibroblasts also secrete TNF. Human milk also contains this factor. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL-2, GM-CSF, SP, Bradykinin, Immune complexes, inhibitors of cyclooxygenase and PAF (platelet activating factor). Human TNF-alpha is a non-glycosylated protein of 17kD and a length of 157aa. Murine TNF-alpha is N-glycosylated. Homology with TNF-beta is approximately 30%. TNF-alpha forms dimers and trimers. Source: Recombinant protein corresponding to rat TNF expressed in E. coli. Molecular Weight: ~17kD Biological Activity: Th |
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| Size | 20ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF, Recombinant, Rat (TNF-Alpha, Cachectin, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-A, Tnfa, Tnfsf2, Tumor Necrosis Factor, Tumor Necrosis Factor Alpha) |
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| Gene, Accession, CAS # | SwissProt: P16599 |
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| Catalog # | 500507 |
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| Order / More Info | TNF, Recombinant, Rat from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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