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| Product Name | TNF-R1,Fc, Recombinant, Human |
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| Description | Purity >95% (SDS-PAGE). TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Biological Activity: TNF-R1:Fc fusion protein blocks TNF-alpha-mediated biological effect with an inhibitory activity in a concentration range of 0.1 to 1ug/ml. Sequence: The extracellular domain of human TNF-R1 (aa 22-211) is fused to the Fc portion of human IgG1. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF-R1,Fc, Recombinant, Human (p55, CD120a, TNFRSF 1A, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNF Receptor 1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 45343 |
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| Order / More Info | TNF-R1,Fc, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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