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| Product Name | SUMO1, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO1 functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. Still, unlike ubiquitin which targets proteins for degradation, SUMO1 is involved in a variety of cellular processes, for example nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 is not active until the last four amino acids of the carboxy-terminus are cleaved off. The active recombinant SUMO-1 protein is derived from the precursor pro-SUMO-1 (Accession # NM_003352). Human SUMO-1 shares 46% and 47% identity with SUMO-2 and SUMO-3 respectively. SUMOylation can occur without the requirement of a specific E3 ligase activity, where SUMO is transferred directly from UbcH9 to specific substrates. SUMOylated substrates are primarily localized to the nucleus (RanG |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SUMO1, Recombinant, Human (Small Ubiquitin-related Modifier 1, SUMO-1, Sentrin, Ubiquitin-like Protein SMT3C, SMT3 Homolog 3, Ubiquitin-homology Domain Protein PIC1, Ubiquitin-like Protein UBL1, GAP-modifying Protein 1, GMP1, SUMO1, SMT3C, SMT3H3, UBL1, PIC1, SMT3, DAP-1, OFC10, SENP2) |
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| Gene, Accession, CAS # | SUMO1, Gene ID: 7341, SwissProt: P63165 |
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| Catalog # | 220290 |
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| Order / More Info | SUMO1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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