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| Product Name | SUMO3, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). SUMO modification has been implicated in functions such as nuclear transport, chromosome segregation and transcriptional regulation. SUMO functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. Still, unlike ubiquitin which targets proteins for degradation, SUMO is involved in a variety of cellular processes, for example nuclear transport, transcriptional regulation, apoptosis, and protein stability. The active recombinant SUMO-3 is derived from the precursor pro-SUMO-3 (Accession # NM_006936). Human SUMO-3 shares 47% and 87% identity with SUMO-1 and SUMO-2 respectively. SUMOylation can occur without the requirement of a specific E3 ligase activity, where SUMO is transferred directly from UbcH9 to specific substrates. SUMOylated substrates are primarily localized to the nucleus (RanGAP-1, RANBP2, PML, p53, Sp100, HIPK2) but there are also cytosolic substrates (IkBa, GLUT1, GLUT4). SUM |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SUMO3, Recombinant, Human (Small Ubiquitin-related Modifier 3, SUMO-3, SMT3 Homolog 1, SUMO-2, Ubiquitin-like Protein SMT3A, SMT3A, SMT3H1) |
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| Gene, Accession, CAS # | SUMO3 |
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| Catalog # | 220293 |
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| Price | |
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| Order / More Info | SUMO3, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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