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| Product Name | MCTS1, Recombinant, Human, aa1-181, His-SUMO-Tag (Malignant T-cell-amplified Sequence 1) |
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| Description | Purity ~90% (SDS-PAGE). Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels rains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphory |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Multiple copies T-cell malignancies |
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| Gene, Accession, CAS # | SwissProt: Q9ULC4 |
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| Catalog # | 374170 |
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| Order / More Info | MCTS1, Recombinant, Human, aa1-181, His-SUMO-Tag (Malignant T-cell-amplified Sequence 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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