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| Product Name | Recombinant Human Suppressor of cytokine signaling 1 |
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| Description | 1-211aa; Full Length. MW: 27.6kD. Purity >90% as determined by SDS-PAGE. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LI |
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| Size | 0.01 mg (Yeast), 0.05 mg (Yeast), 0.1 mg (Yeast), 0.2 mg (Yeast), 0.05 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [JAK-binding protein; JABSTAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3] |
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| Gene, Accession, CAS # | SOCS1, Gene ID: 8651, Accession: NP_003736.1 |
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| Catalog # | MBS1231200 |
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| Order / More Info | Recombinant Human Suppressor of cytokine signaling 1 from MYBIOSOURCE INC. |
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| Product Specific References | Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) familySSI-2 and SSI-3.Minamoto S., Ikegame K., Ueno K., Narazaki M., Naka T., Yamamoto H., Matsumoto T., Saito H., Hosoe S., Kishimoto T.Biochem. Biophys. Res. Commun. 237:79-83(1997) SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.Ohya K., Kajigaya S., Yamashita Y., Miyazato A., Hatake K., Miura Y., Ikeda U., Shimada K., Ozawa K., Mano H.J. Biol. Chem. 272:27178-27182(1997) A family of cyto |
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