| 产品详情 |
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| Product Name | Vps34-IN-1 |
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| Description | Purity >98%. Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34; IC50 = 25 nM in vitro ). It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 dose-dependently inhibits generation of PtdIns-(3)-p, which is essential to the formation and trafficking of endsomes and autophagosomes, without affecting the ability of class I PI3K to regulate Akt. It induces a rapid and pronounced loss of phosphorylation on serum- and glucocorticoid-regulated kinase 3. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[[2-[(2-chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino]-2-methyl-2-propanol, Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1 |
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| Gene, Accession, CAS # | CAS: 1383716-33-3 |
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| Catalog # | LS-H10457 |
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| Order / More Info | Vps34-IN-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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