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| Antigenic Specificity | Ficolin-2, Human |
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| Clone | GN5 |
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| Host Species | Mouse |
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| Reactive Species | human, rat |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | frozen sections, immunoassay, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody GN5 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2/P35 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2/P35 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2/P35 -MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2/P35 also shows opsonic activity. |
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| Immunogen | n/a |
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| Other Names | Ficolin-2/P35, L-ficolin, ficolin L, EBP-37, hucolin, 37 kDa elastin-binding protein, Collagen/fibrinogen domain-containing protein 2, Ficolin-B, Ficolin-beta. |
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| Gene, Accession # | FCN2, FCNL |
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| Catalog # | HM2091 |
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| Order / More Info | Ficolin-2, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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