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| Product Name | Phosphodiesterase 4D3, Recombinant, Human, GST-Tag (PDE4D3) |
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| Description | Purity ≥70%. Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5; 1, 2). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein-protein interactions with cytoskeletal scaffolding proteins. Description: Recombinant human PDE4D3 (GenBank Accession No. NM_006203, full length, with N-terminal GST tag, expressed in an Baculovirus infected Sf9 cell expression system. Specific Activity: ~5000pmol/min/ug Assay Conditions: 10mM Tris-HCl, pH 7.4 |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: U50159 |
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| Catalog # | P4072-03W |
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| Order / More Info | Phosphodiesterase 4D3, Recombinant, Human, GST-Tag (PDE4D3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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