| 产品详情 |
| Edit |   |
|---|
| Product Name | CK1 Gamma 2, Recombinant, Human, GST-Tag (CSNK1G2, CK1G2) |
|---|
| Description | Purified (~70-90%). CK12 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK12 is a ubiquitously expressed cytoplasmic kinase that can interact and phosphorylate the metastatic tumor antigen 1 short form (MTA1s) co-localizing it in the cytoplasm. Phosphorylated MTA1s then sequesters the estrogen receptor-alpha in the cytoplasm of breast cancer cells. CK12 hyperphosphorylates the ceramide transfer protein CERT leading to a decrease in de novo sphingomyelin synthesis. The reduction in synthesis of sphingomyelin is reversed by the expression of CERT mutants that are not hyperphosphorylated. Source: Recombinant protein corresponding to human CK1 Gamma 2 fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~73kD Specific Activity: 30nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Accession: NM_001319 |
|---|
| Catalog # | 499890 |
|---|
| Price | |
|---|
| Order / More Info | CK1 Gamma 2, Recombinant, Human, GST-Tag (CSNK1G2, CK1G2) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|