| 产品详情 |
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| Antigenic Specificity | MRP-8, Human |
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| Clone | 7C12/4 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgM |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | FC, immunoassay, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody 7C12/4 recognizes an epitope on the S100A8 (MRP-8) protein. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. |
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| Immunogen | n/a |
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| Other Names | S100A8 |
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| Gene, Accession # | n/a |
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| Catalog # | HM2175 |
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| Price | |
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| Order / More Info | MRP-8, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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