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| Antigenic Specificity | Peripheral myelin protein 22, Human |
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| Clone | CF1 |
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| Host Species | Mouse |
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| Reactive Species | human, rhesus monkey |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | immunoassay, paraffin sections, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The monoclonal antibody CF1 recognizes human peripheral myelin protein 22 (PMP22). PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy. Monoclonal antibody CF1 is crossreactive with Rhesus monkey PMP22. |
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| Immunogen | Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue (CRHPEWHLNSDYSYG) |
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| Other Names | Growth arrest-specific protein 3, Gas-3 |
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| Gene, Accession # | n/a |
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| Catalog # | HM2219 |
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| Price | |
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| Order / More Info | Peripheral myelin protein 22, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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