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| Product Name | Dimethyl fumarate |
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| Description | Purity >95%. Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways. It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate. Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels. It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis. Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2E-butenedioic acid, 1,4-dimethyl ester, NSC 167432, NSC 25942, trans-Butenedioic Acid dimethyl ester |
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| Gene, Accession, CAS # | CAS: 624-49-7 |
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| Catalog # | LS-H7465 |
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| Order / More Info | Dimethyl fumarate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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