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| Product Name | sCD59, Human, ELISA kit |
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| Description | CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. Complement activation ultimately leads to formation of the cytotoxic, poreforming membrane attack complex (MAC), the main effector of complement-mediated tissue damage. Insertion of the MAC into cell membranes induces the release of cytokines and growth factors that promote inflammation, thrombosis, and cell proliferation. CD59 is a complement regulatory protein ubiquitously expressed on mammalian cell surfaces and it specifically inhibits MAC formation and thereby protects ``self'' cells from complement-mediated damage. The protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in the CD59 gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. CD59 was demonstrated to be present in plasma/serum of healthy individuals in levels ranging from 22 to 119 ng/ml. Cross Reactivity: Mouse - No , Pig - No , Rat - No |
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| Size | 2 x 96 det. |
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| Concentration | n/a |
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| Applications | Immunoassay |
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| Other Names | CD59 glycoprotein, MAC-inhibitory protein, MAC-IP, membrane inhibitor of reactive lysis, MIRL, Protectin Sandwich ELISA kit, EIA, enzyme immunoassay, assay |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | HK374-02 |
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| Order / More Info | sCD59, Human, ELISA kit from HYCULT BIOTECH |
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| Product Specific References | n/a |
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