| 产品详情 |
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| Antigenic Specificity | HEF1 |
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| Clone | 2G9 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat, human |
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| Isotype | IgG1 kappa |
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| Format | Protein G purified |
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| Size | 50ul |
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| Concentration | 1mg/ml |
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| Applications | WB, IP, ICC/IF, IHC-Fr, Flow Cyt |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse Anti-HEF1 [2G9]. Does not recognize p130 Cas. Not tested on Sin1. This antibody mostly detects HEF1 localized at the focal adhesion sites |
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| Immunogen | Fusion protein, corresponding to amino acids 82-398 of Human HEF1. |
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| Other Names | CAS L, Cas like docking, CASL, Crk associated substrate related protein; dJ49G10.2, dJ761I2.1, Enhancer of filamentation 1, HEF 1, NEDD 9; NEDD9, NEDD9 protein, Neural cell expressed developmentally down regulated 9; Neural precursor cell expressed developmentally down regulated 9, NY REN 12 antigen; p105, Protein NEDD9 |
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| Gene, Accession # | n/a |
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| Catalog # | IQ296 |
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| Price | |
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| Order / More Info | HEF1 Antibody from IMMUQUEST LTD. |
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| Product Specific References | Kondo S et al. Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer.Clin Cancer Res. 2012 Nov 15;18(22):6326-38. doi: 10.1158/1078-0432.CCR-11-2162. Epub 2012 Oct 4.WB ; Human PMID: 23037767 Bradbury P et al. PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9.Biochim Biophys Acta. 2012 Feb;1823(2):290-7. doi: 10.1016/j.bbamcr.2011.10.011. Epub 2011 Oct 28.IP WB ; Human PMID: 22061964 NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration.Zhong J et al. PLoS One. 2012;7(4):e35058. doi: 10.1371/journal.pone.0035058. Epub 2012 Apr 11 PMID: 22509381 The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway. Tomkiewicz C et al. Oncogene. 2012 Jun 4. doi: 10.1038/onc.2012.197. [Epub ahead of print] PUBMED Li Y et al. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.Oncogene. 2011 Jun 9;30(23):2633-43. doi: 10.1038/onc.2010.632. Epub 2011 Feb 14. ICC/IF IHC WB ; Human, Mouse PMID: 21317929 Bradshaw LN et al. Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells.Biochim Biophys Acta. 2011 Feb;1813(2):340-5. doi: 10.1016/j.bbamcr.2010.11.018. Epub 2010 Dec 8.WB ; Human PMID: 21145356 Hivert V et al. Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation.Biochem Pharmacol. 2009 Oct 15;78(8):1017-25. doi: 10.1016/j.bcp.2009.06.005. Epub 2009 Jun 17.WB ; Human PMID: 19539609 Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. Bui LC et al. Oncogene. 2009 Oct 15;28(41):3642-51. doi: 10.1038/onc.2009.224. Epub 2009 Aug 3.ICC/IF WB ; Human PMID: 19648964 Natarajan M et al. HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells.Oncogene. 2006 Mar 16;25(12):1721-32. ICC/IF IP WB ; Human PMID: 16288224 Bargon SD et al. The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions.Biochim Biophys Acta. 2005 Dec 15;1746(2):143-54. Epub 2005 Nov 14.ICC/IF WB ; Human, Rat PMID: 16344118 Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. ONeill GM ( Molecular and Cellular Biology,Aug 2001)PMID:11438665 |
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