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| Product Name | PYCR1, 1-319aa, Human, His tag, E Coli (Bioactivity Validated) |
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| Description | MW: 35.5 kDa (339aa), confirmed by MALDI-TOF. Purity >90% by SDS-PAGE. PYCR1 is a universal housekeeping enzyme that catalyzes the NAD (P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP (+) in some cell types. It forms a homopolymer and localizes to the mitochondrion. Defects in PYCR1 are the cause of cutis laxa autosomal recessive type 2B (ARCL2B). Recombinant human PYCR1 protein, fused to His-tag at N-terminus |
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| Size | 0.05 mg, 0.25 mg |
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| Concentration | 0.5 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [Pyrroline-5-carboxylate reductase 1; ARCL2B; P5C; P5CR; PIG45; PP222; PRO3] |
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| Gene, Accession, CAS # | PYCR1, Gene ID: 5831, Accession: NP_008838 |
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| Catalog # | MBS203950 |
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| Order / More Info | PYCR1, 1-319aa, Human, His tag, E Coli (Bioactivity Validated) from MYBIOSOURCE INC. |
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| Product Specific References | Kornak u., et al. (2009) Nat Genet. 41 (9):1016-21.; Rao Z., et al (2006) J Mol Biol. 359 (5):1364-77. |
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