| 产品详情 |
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| Product Name | ABT-263 |
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| Description | Purity >98%. The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. ABT-263 is a potent, orally bioavailable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, like Bim, leading to apoptosis. ABT-263, alone, can induce regression of some tumors in some xenograft mouse models of cancer. It can also potentiate the therapeutic efficacy of chemotherapeutic compounds. Interestingly, ABT-263 induces apoptosis in cancer cell lines expressing mutants of Beta-catenin 1, a Wnt signaling factor commonly mutated in a range of cancer types. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide, Navitoclax, A-855071 |
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| Gene, Accession, CAS # | CAS: 923564-51-6 |
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| Catalog # | LS-H6375 |
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| Order / More Info | ABT-263 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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