| 产品详情 |
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| Product Name | Licofelone |
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| Description | Purity >98%. Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1Beta (IL-1Beta) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1Beta expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone's affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid, ML 3000 |
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| Gene, Accession, CAS # | CAS: 156897-06-2 |
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| Catalog # | LS-H8473 |
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| Order / More Info | Licofelone from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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