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| Product Name | Fas, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Fas (fibroblast associated; also known as APO1 or CD95) is a member of the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6 (13). The human Fas precursor is 335 amino acids (aa) in length, and contains a 25 aa signal peptide, a 148 aa extracellular domain (ECD), a 17 aa transmembrane sequence, and a 145 aa cytoplasmic region. The ECD possesses three cysteinerich TNFR repeats, while the cytoplasmic region contains one death domain (DD) that is required for the transduction of apoptotic signals (4). Human Fas ECD shares 55%, 58% 62% 63% and 64% aa sequence identity with mouse, rat, feline, bovine and porcine Fas ECD, respectively. A human Fas isoform of 314 aa that lacks the transmembrane sequence is secreted by resting lymphocytes, while isoforms of 149, 132, 103 and 86 aa that also lack the DD and show substitutions for parts of the TNFR repeats are less prominently expressed (46). All five isoforms block the extrinsic apopt |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Fas, Recombinant, Human (NFRSF6/CD95 Fc Chimera, Fibroblast-associated, Apo-1, APT1, CD95, TNFRSF6) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 167648 |
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| Order / More Info | Fas, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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