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| Antigenic Specificity | Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC) |
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| Clone | 2F2-A3-H10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The protein encoded by this gene belongs to the protein phosphatase family,PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes,including cell division. It is expressed in mammalian cells as three closely related isoforms,alpha,beta/delta and gamma,which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,Oct 2011]Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1(PP1)is essential for cell division,and participates in the regulation of glycogen metabolism,muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex,which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Subunit structure: PP1 comprises a catalytic subunit,PPP1CA,PPP1CB or PPP1CC,which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3,and then complexed to one or several targeting or regulatory subunits. PPP1R12A,PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A(in skeletal muscle),PPP1R3B (in liver),PPP1R3C, PPP1R3D and PPP1R3F(in brain)mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin,disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform gamma-2 interacts with SPZ1 By similarity. Component of the MLL5-L complex,at least composed of MLL5,STK38,PPP1CA,PPP1CB,PPP1CC,HCFC1,ACTB and OGT. Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B,PP1 and NCK1/2. Interacts with IKFZ1,the interaction targets PPP1CC to pericentromeric heterochromatin,dephosphorylates IKAROS,stabilizes it and prevents it from degradation. Interacts with PPP1R42,the interaction is direct By similarity. Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex,composed of PPP1R10/PNUTS,TOX4,WDR82,and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1,the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Subcellular location: Cytoplasm. Nucleus. Nucleus ? nucleolus. Nucleus ? nucleoplasm. Nucleus speckle. Chromosome ? centromere ? kinetochore. Cleavage furrow. Midbody. Mitochondrion. Sequence similarities: Belongs to the PPP phosphatase family. PP-1 subfamily. |
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| Immunogen | Purified recombinant human PP1C protein fragments expressed in E.coli. |
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| Other Names | PP-1G|ppp1g|PP1|dis2m1|fe06g11|fi22e08|wu:fe06g11|wu:fi22e08|PP1C|PPP1G|Ppp1cc1|ppp1cc-a |
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| Gene, Accession # | Gene ID: 5501 |
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| Catalog # | ABIN1558174 |
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| Price | |
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| Order / More Info | Protein Phosphatase 1, Catalytic Subunit, gamma Isoform (PPP1CC) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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