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| Product Name | SMAD4, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). SMAD4 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription acts as a tumor suppressor. SMAD4 is a target molecule for functional inactivation in cervical cancer. SMAD4 is an important biomarker for malignant transformation atakes part in inducing apoptosis by modulating Bcl-2/Bax balance. Source: Recombinant corresponding to aa1-467 from human SMAD4, expressed in E.coli. Molecular Weight: ~54.4kD AA Sequence: MGSSHHHHHH SSGLVPRGSH MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE LEKAITTQNC NTKCVTIPSTCSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLVPRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQ |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SMAD4, Recombinant, Human (Mothers Against Decapentaplegic Homolog 4, SMAD 4, Mothers Against DPP Homolog 4, Deletion Target In Pancreatic Carcinoma 4, MAD Homolog 4, SMAD Family Member 4, hSMAD4, DPC4, MADH4) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 136959 |
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| Order / More Info | SMAD4, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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