| 产品详情 |
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| Product Name | ERK Kinase Kinase 5 Inhibitor |
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| Description | Purity ~99% (HPLC). A cell-permeable imidazopyridine compound that acts as a potent, ATP-binding site-targeting ASK1/MEKK5-selective inhibitor (IC50 = 14 and 500nM, respectively, against ASK1 and ASK2/MEKK6), while exhibiting much reduced or no activity toward a panel of 195 other kinases. Shown to inhibit STZ- (1 mM) induced JNK and p38 phosphorylation in INS-1 pancreatic beta cells (IC50 <300nM) and be orally available in rats in vivo. Primary Target: ASK1/MEKK5 Primary Target IC50: 14 and 500nM, respectively, against ASK1 and ASK2/MEKK6 Molar Mass: 432.4 Solubility: DMSO or H2O |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ERK Kinase Kinase 5 Inhibitor (N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide, 2HCl, N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(2-methyl-2-propanyl)benzamide, 2HCl, 4-tert-Butyl-N-(6-(1H-imidazol-1-yl)imidazo(1,2-a)pyridin-2-yl)benzamide, 2HCl, Apoptosis Signal-Regulating Kinase 1 Inhibitor, ASK-1 Inhibitor, MAP Kinase Kinase Kinase 5 Inhibitor, MAP3K5 Inhibitor, MAPKKK5 Inhibitor, MEKK5 Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217346 |
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| Order / More Info | ERK Kinase Kinase 5 Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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