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| Product Name | NT-1, Recombinant, Human (Neurotrophin 1/B Cell Stimulating Factor 3, BCSF-3) |
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| Description | Purity ≥ 98% by SDS-PAGE and HPLC analyses. Human NT-1/BCSF-3 (Neurotrophin-1/B-Cell Stimulating Factor-3) is identi?ed as part of the IL-6 family of cytokines. It is most homologous to cardiotrophin-1 and ciliary neurotrophic factor. NT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member beta (LIFR-b) and induces tyrosine phosphorylation of these receptors. In vitro, it supports survival of chick embryo motor and sympathetic neurons. In mice, NT-1/BCSF-3 includes serum amyloid A, causes body weight loss and B cell hyperplasia associated with increase in serum IgG and IgM. Recombinant human NT-1/BCSF-3 is a 22.4kD protein containing 199 amino acid residues. AA Sequence: MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPG |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N5399 |
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| Order / More Info | NT-1, Recombinant, Human (Neurotrophin 1/B Cell Stimulating Factor 3, BCSF-3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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