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| Product Name | Granzyme A, Recombinant, Mouse, aa29-260, His-B2M-Tag (Gzma) |
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| Description | Purity ~85% (SDS-PAGE). Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). Source: Recombinant protein corresponding to aa29-260 from mouse Gzma, fused to His-B2M-Tag at N-terminal, expressed in E. coli. AA |
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| Size | 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P11032 |
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| Catalog # | 370636 |
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| Order / More Info | Granzyme A, Recombinant, Mouse, aa29-260, His-B2M-Tag (Gzma) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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