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| Product Name | Granzyme B (Granzyme-2) Activity Kit (Fluorometric) |
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| Description | Granzyme B (GZMB, EC number 3.4.21.79) also known as Granzyme 2 is a serine protease stored in the granules of activated cytotoxic Tcells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell.With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes andactivates various pro caspases thereby inducing apoptosis in the target cell. In LSBio's Granzyme B Activity Assay Kit, we have utilized apeptide substrate containing the Granzyme B recognition sequence along with a fluorescent label 'AFC'. Granzyme B catalyzes the cleavageof this substrate and releases the AFC molecule, which can be detected fluorometrically (Ex/Em = 380/500 nm). This Assay Kit is rapid,reliable and sensitive and can detect Granzyme B activity in various biological samples. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | This assay provides for the detection of Granzyme B activity in various biological samples or purified Granzyme B activity, screening Granzyme B inhibitors, or characterize/Study Granzyme B inhibitors. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-K56 |
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| Order / More Info | Granzyme B (Granzyme-2) Activity Kit (Fluorometric) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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