| 产品详情 |
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| Product Name | CXCR4 Antagonist III |
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| Description | Purity ~99% (HPLC). A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50=36.2nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10uM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50=100.1 and 41nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6mg/kg, s.c). Formula: C30H43N7•2HCl Molecular Weight: 574.6 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CXCR4 Antagonist III (Fusin Antagonist III, N2-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N4-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217300 |
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| Price | |
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| Order / More Info | CXCR4 Antagonist III from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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