| 产品详情 |
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| Product Name | CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV) |
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| Description | Purity ~95% (HPLC). A 14-aa internally disulfide-bonded peptide that potently competes against SDF-1alpha/CXCL12 for CXCR4 binding (IC50 = 0.91nM; [SDF-1] = 100nM) and protects MT-4 cells against X4-HIV strain HIV-1IIIB infection (EC50 = 4nM in 5 d; MOI = 0.01) with no significant cytotoxicity (CC50 = 56uM; 5 d). Inhibits SDF-1-induced Ca2+ mobilization (IC50 = 4.5nM; [SDF-1] = 30nM; CXCR4-expressing CHO cells) in vitro and effectively prevents CXCR4-dependent 5BC-5 metastasis in NK-depleted SCID mice in vivo (10mg/kg i.p.) in vivo. Formula: C101H145FN34O18S2.xH2O Sequence: N alpha-4-fluorobenzoyl-Arg-Arg-Nal-Cys4-Tyr-Cit-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys?3-Arg-NH2 (Disulfide bond: 4 → 13; Nal = L-3-(2-naphthyl)alanine; Cit = L-citrulline) Solubility: H2O Primary Target: CXCR4 Primary Target IC50: 0.9nM Molar Mass: 2206.58 |
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| Size | 2mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217301 |
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| Order / More Info | CXCR4 Antagonist IV, TF14016 (Fusin Antagonist IV) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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