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| Product Name | PHAP I, IN, Control Peptide (Putative HLA DR-associated Protein) |
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| Description | Synthetic peptide corresponding to amino acids close to C-terminus of human PHAP I (1). This sequence is identical between human and rat PHAP I. Corresponding antibody detects PHAP I. Species Crossreactivity: human and rat PHAP I. Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3,-6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins ( PHAPs ) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P3368-03A |
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| Order / More Info | PHAP I, IN, Control Peptide (Putative HLA DR-associated Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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