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| Product Name | MEK1 Inhibitor (PD98059, 2'-amino-3'-methoxyflavone) |
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| Description | Highly Purified (~99%). PD98059 (MEK1 Inhibitor) has been shown to act in vivo as a highly selective inhibitor of MEK1 activation and the MAP kinase cascade (1-4). PD98059 binds to the inactive forms of MEK1 and prevents activation by upstream activators such as c-Raf (3) Specificity: Inhibits activation of MEK1 and MEK2 with IC50 values of 4uM and 50uM, respectively (1-3). Testing has shown that PD98059 does not inhibit activation of other highly related dual-specificity protein kinases or the activity of over 18 other Ser/Thr protein kinases (3). As shown in the Western Blot, at concentrations up to 100uM PD98059 does not inhibit activation of MKK3 or SEK (MKK4) as determined by measuring phosphorylation at its activation site. We have also found no inhibition of MKK6 or related family members. Solubility: Soluble in anhydrous DMSO at 25mg/ml. Very poorly soluble in water. Applications: Suitable for use in in vitro or cell-based assays. |
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| Size | 1.5mg, 5mg |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | 2-(2-amino-3-methoxyphenyl)-4H-1-Benzopyran-4-one; 2-(2'-Amino-3'-methoxy)-flavone; 2-(2-amino-3-methoxyphenyl)-chromone |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M2865-17A |
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| Order / More Info | MEK1 Inhibitor (PD98059, 2'-amino-3'-methoxyflavone) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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