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| Product Name | ADAR, Recombinant, Human, aa1-176, GST-Tag (Double-stranded RNA-specific Adenosine Deaminase) |
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| Description | Purity ~90% (SDS-PAGE). Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 136kD double-stranded RNA-binding protein, p136Interferon-inducible protein 4, IFI-4K88DSRBP |
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| Gene, Accession, CAS # | SwissProt: P55265 |
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| Catalog # | 372144 |
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| Order / More Info | ADAR, Recombinant, Human, aa1-176, GST-Tag (Double-stranded RNA-specific Adenosine Deaminase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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