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| Product Name | 451Lu BR Viable Cells (1 x 10^6 cells) |
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| Description | 451Lu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451Lu BR cells produce xenograft tumors when injected into immunocompromised mice. |
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| Size | 1 mL |
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| Concentration | 1x10E6 |
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| Applications | The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways. |
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| Other Names | Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 451Lu BR-01-0001 |
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| Order / More Info | 451Lu BR Viable Cells (1 x 10^6 cells) from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | n/a |
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