| 产品详情 |
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| Product Name | AG-1296 |
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| Description | MW: 266.3. Purity ≥98% (TLC); NMR (Conforms). PDGFR InhibitorA potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl1. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [AAL-993; 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide; 6,7-Dimethoxy-3-phenylquinoxaline] |
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| Gene, Accession, CAS # | CAS: 146535-11-7 |
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| Catalog # | MBS515076 |
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| Order / More Info | AG-1296 from MYBIOSOURCE INC. |
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| Product Specific References | 1. PW Manley et al. J. Med. Chem. 2002 45:5687 2. PW Manley et al. Biochim. Biophys. Acta 2004 1697:17 |
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