| 产品详情 |
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| Product Name | AG-490 |
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| Description | MW: 294.3. Purity >98% (TLC); NMR (Conforms). JAK-2 inhibitorSelective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively). Binds to the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Cell permeable.Scientific Background: A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly e |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [STO-609; 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate; (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide] |
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| Gene, Accession, CAS # | CAS: 133550-30-8 |
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| Catalog # | MBS515068 |
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| Order / More Info | AG-490 from MYBIOSOURCE INC. |
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| Product Specific References | 1. H Tokumitsu et al. J. Biol. Chem. 2002 277:15813 2. H Tokumitsu et al. J. Biol. Chem. 2003 278:10908 3. M Kukimoto-Niino et al. J. Biol. Chem. 2011 286:22570 |
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