| 产品详情 |
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| Product Name | AG-879 |
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| Description | MW: 316.5. Purity >98% (TLC); NMR (Conforms). NGFR inhibitorA selective PI 3-Kg isoform inhibitor (IC50 = 0.24, 1.45, 0.07 and 1.70 uM for a, b, g and d isoforms respectively). Blocks neutrophil recruitment and displays anti-inflammatory activity1. Active in vivo.Scientific Background: Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells (1). Displays antitumor activity in a mouse model (2). Blocks the ETK-PAK1 interactio |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [AS-041164 ; 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione; NSC31098; alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide] |
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| Gene, Accession, CAS # | CAS: 148741-30-4 |
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| Catalog # | MBS515054 |
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| Price | |
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| Order / More Info | AG-879 from MYBIOSOURCE INC. |
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| Product Specific References | 1. C Ferrandi et al. J. Pharmacol. Exp. Ther. 2007 322:923 |
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