| 产品详情 |
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| Product Name | PCSK9 |
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| Description | Purified (~85%). PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. The D374T mutation results in higher affinity of PCSK9 for LDLR. Source: Recombinant protein corresponding to aa31-692 from human PCSK9, fused to C-terminal His- and Avi-tags and a D374T mutation, expressed in HEK293 cells. Molecular Weight: ~74kD, PCSK9 is autocleaved to the ~14kD prodomain (aa31-152) and the ~60kD mature form (aa153-692), which run at higher MW by |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PCSK9 (D374T), Recombinant, Human, aa31-692 (Biotin) (Proprotein Convertase Subtilisin/Kexin Type 9, FH3, HCHOLA3, PC9) |
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| Gene, Accession, CAS # | Accession: NM_174936, SwissProt: Q8NBP7 |
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| Catalog # | 298444 |
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| Price | |
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| Order / More Info | PCSK9 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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