| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 50 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Cool/Pix proteins comprise a family of guanine nucleotide exchange factors (GEFs) localized to focal adhesions. The family consists of two isoforms, cool2/alphapix and cool1/betaPix, the latter having two splice variants that vary in their carboxy termini . Cool1/betaPix, like other GEFs, has a DH (Dbl homology) domain, which allows binding of small GTPases and GDP/GTP exchange, and a PH (Pleckstrin homology) domain, which is important in regulating subcellular localization. Cool1/betaPix also has an SH3 domain, which binds to the PAK kinase, a downstream effector of cdc42 and Rac . Phosphorylation of cool1/betaPix by PAK2 downstream of MAPK signaling alters the localization of a complex containing PAK2 and cool-1/betaPix, regulating formation of growth cones in response to growth factors . Growth factor induced activation of Rac1 via cool1/betaPix was later shown to occur independently of subcellular localization . Endothelin-1 stimulation of mesangial cells stimulates the protein kinase A (PKA) pathway, resulting in translocation of cool-1/betaPix and activation of cdc42 . Synonyms: ARHGEF7,BETA-PIX,COOL1,DKFZp686C12170,DKFZp761K1021,KIAA0142,KIAA0412,Nbla10314,P50,P50BP,P85,P85COOL1,P85SPR,PAK3,PIXB , |
|---|
| Immunogen | Recombinant protein of human ARHGEF7 |
|---|
| Other Names | cool1|p50|p85|pak3|pixb|ARHGEF7|BETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB|P85spr|Pak3bp|Cool|PIX|betaPix|betaPix-b|betaPix-c|cool-1|mKIAA0142|p85Cool1|p85SPR |
|---|
| Gene, Accession # | Gene ID: 8874,54126,114559 |
|---|
| Catalog # | ABIN1683378 |
|---|
| Price | |
|---|
| Order / More Info | rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|