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| Product Name | (5Z)-7-Oxozeaenol |
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| Description | Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro. Purity 98%. MW (observed): 362.37 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
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| Gene, Accession, CAS # | CAS: 253863-19-3 |
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| Catalog # | 3604/1 |
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| Order / More Info | (5Z)-7-Oxozeaenol from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 20663880, 22057290, 22683931, 23403560, 24175906, 24531446, 25512613, 25514175, 25557171, 25927238, 27558154, 27605380, 27768832, 27820799, 28506461, 28569204, 28714004, 29163172, 29777109 |
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